GSK sees blockbuster potential in targeted cancer therapy after promising early data

Published Sun, Apr 12, 2026 · 10:39 PM

[LONDON] British drugmaker GSK’s experimental targeted cancer drug Mo-rez has blockbuster potential, its head of oncology research has told reporters, after early data showed the drug helped shrink tumours in patients with advanced, hard-to-treat cancers.

“This is one of our priority assets at this stage,” GSK’s senior vice-president, global head oncology, research and development Hesham Abdullah said on a call with journalists discussing the early data, which is being presented at a medical conference in Puerto Rico on Sunday (Apr 12).

“Do we think it would be a blockbuster? Yes, absolutely,” he said.

Initial results measured the proportion of patients who achieved a meaningful reduction in tumour size, defined as at least a 30 per cent shrinkage. In platinum-resistant ovarian cancer, 62 per cent of patients met that threshold, while 67 per cent did so in endometrial cancer.

Analysts have not yet projected future sales for Mo-rez given early trial data.

The data gives momentum to GSK’s fast-growing oncology business. CEO Luke Miels, who started in the role in January, has said the company will speed up work on new medicines, a shift Abdullah said is already being reflected in its product development.

“I think it has been reflected in the type of pace that you are seeing and the type of conviction that we have in our programmes moving forward,” he added.

GSK is testing Mo-rez in two late-stage trials in ovarian and endometrial cancers, and plans to start three additional studies in coming months.

Mo-rez, an antibody-drug conjugate, targets the B7H4 protein found on gynaecological cancer cells but is largely absent from healthy tissue. The market for antibody-drug conjugate treatments is projected to reach US$31 billion by 2030.

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GSK licensed the drug from China’s Hansoh Pharma in 2023. REUTERS